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Price of atorvastatin 20 mg /day and the percentage reduction in incidence of MI and stroke. Our primary endpoint was the change in incidence of MI, with atorvastatin (20 mg) or placebo as the comparator at 12 months. Secondary data, including the composite endpoint, included all-cause mortality, risk of fatal coronary events (MI and death), the composite endpoint of death in the first year of follow-up. We conducted 2 parallel-group trials (13, 16) in individuals aged 60 to 79 years and 2 multicenter trials (17, 18) in older individuals; general, we aimed to enroll at least 200 patients per study arm. Both clinical trial arms were blinded at study entry. The trials were published in 2008. Subjects The NIH ClinicalTrials.gov registry is global repository for prospective, randomized clinical trials. We included studies in which atorvastatin 20 mg was added to treatment of patients with stable coronary artery disease who were treated for at least 1 year with stable angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, were diagnosed with or at the time of randomization had CAD or stable coronary artery disease. We excluded trials in which atorvastatin was added conjunction with other agents for the prevention of CAD (eg, statins). We defined risk of fatal CHD events or cardiovascular deaths of CHD events, including MI, as an incidence rate that exceeded 1.5 deaths per 10,000 person-years in patients who were treated for a year. We did not define MI in the absence of CAD as first event; in those cases, the death was coded as nonfatal MI if an angiogram was performed or if electrocardiogram did not show a noncoronary cause of death. We defined a composite endpoint of coronary death, stroke, or MI and stroke as death in the first year after randomized enrollment in patients who were not undergoing treatment and did receive atorvastatin 20 mg. The cohort in each trial and site followed up to the end of randomization period unless the Ator 250mg $257.76 - $0.72 Per pill trial was terminated and study no longer ongoing. Study Design We considered the trials that included atorvastatin 20 mg in combination with other drugs or in which patients were assessed before randomization but not enrollment. We included trials that had a 3-fold or higher risk of bias, as judged by the Cochrane Collaboration. We excluded trials of individuals with established CAD, MI, or other acute myocardial infarction and the study was terminated before enrollment because of lack sufficient results to include. We also excluded trials that had a baseline LDL cholesterol level of less than or equal to 3.5 mmol/L at enrollment. Randomization. We randomly assigned all patients in 3 separate 1-month arms of 2 a 24-month study for atorvastatin 20 mg. In a randomized dose contrast study, we divided the study into two 8-week arms: treatment with atorvastatin 20 mg once, and treatment with atorvastatin 20 mg twice daily for 24 weeks. Randomization was done in accordance with the Cochrane Collaboration, patients assigned in a 1:1 ratio. the study of atorvastatin 20 mg in combination with other drugs, we divided patients in a 2:1 ratio into placebo and atorvastatin 20 mg groups. In the study atorvastatin 10 mg buy of atorvastatin 20 mg in combination with other drugs, we compared the drug in active group as a comparator with the drug in placebo group, with patients randomly assigned in a 1:1 ratio. the trial of atorvastatin 20 mg, we randomized patients into placebo or atorvastatin 20 mg;



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